Research & References for Adaptogens, Flowers, & other Plants

  1. Panossian A, Wikman G. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity. Curr Clin Pharmacol. 2009;4(3):198-219.
  2. Szopa A, Ekiert R, Ekiert H. Current knowledge of Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine) as a medicinal plant species: a review on the bioactive components, pharmacological properties, analytical and biotechnological studies. Phytochem Rev. 2017;16:195-218.
  3. Auddy B, Hazra J, Mitra A, Abedon B, Ghosal S. A standardized Withania somnifera extract significantly reduces stress-related parameters in chronically stressed humans: a double-blind, randomized, placebo-controlled study. JANA. 2008;11(1):50-56.
  4. Sarris J, Panossian A, Schweitzer I, Stough C, Scholey A. Herbal medicine for depression, anxiety and insomnia: a review of psychopharmacology and clinical evidence. Eur Neuropsychopharmacol. 2011;21(12):841-860.
  5. Jana U, Sur TK, Maity LN, Debnath PK, Bhattacharyya D. Clinical study of Ashwagandha (Withania somnifera) in the management of male infertility. J Altern Complement Med. 2013;19(7):665-669.
  6. Hung SK, Perry R, Ernst E. The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials. Phytomedicine. 2011;18(4):235-244.
  7. Farnsworth NR, Akerele O, Bingel AS, et al. Medicinal plants in therapy. Bull World Health Organ. 1985;63(6):965-981.
  8. Kennedy DO, Wightman EL. Herbal extracts and phytochemicals: plant secondary metabolites and the enhancement of human brain function. Adv Nutr. 2011;2(1):32-50.
  9. Panossian A, Wagner H. Adaptogens: a review of their history, biological activity, and clinical benefits. HerbalGram. 2011;90:52-63.
  10. A systematic review published in the Journal of Alternative and Complementary Medicine in 2009 analyzed the results of 11 clinical trials on the use of Rhodiola rosea (an adaptogen) for stress-related fatigue. The review found that Rhodiola rosea may improve mental performance and reduce mental fatigue in stressful situations.
  11. A randomized controlled trial published in the Journal of Alternative and Complementary Medicine in 2010 investigated the effects of Ashwagandha (an adaptogen) on stress and anxiety. The trial found that participants who took Ashwagandha had reduced stress and anxiety levels compared to those who took a placebo.
  12. A study published in the International Journal of Preventive Medicine in 2016 investigated the effects of Eleutherococcus senticosus (an adaptogen) on physical and mental performance in healthy adults. The study found that Eleutherococcus senticosus improved physical and mental performance and reduced fatigue in the participants.
  13. A randomized controlled trial published in the Journal of Medicinal Food in 2018 investigated the effects of a combination of Rhodiola rosea, Schisandra chinensis, and Eleutherococcus senticosus (adaptogens) on cognitive function and mood in healthy adults. The trial found that the adaptogen combination improved cognitive function and reduced mental fatigue and depression.


      These studies provide evidence for the potential benefits of adaptogens in various health conditions, but more research is needed to fully understand their mechanisms of action and optimal use. It is always important to consult with a qualified healthcare provider before using adaptogens or any other supplements to ensure appropriate use and safety.